Operating requirements for cryogenic reactors

### Cryogenic Reactor Operation Steps

1. **Preparation**:

- Rinse the reactor twice with the reaction solvent, analyzing it via GC until impurities are below 0.1%.

- Rinse twice more with a water-free solvent (20-30 kg each time), ensuring the reactor is dry and ready for use.

2. **Loading and Setup**:

- Load the substrate and solvent into the reactor.

- Start stirring, evacuate to -0.1 MPa, and purge with nitrogen to remove other gases.

- Attach a pebble-made liquid seal bottle to the reactor vent.

3. **Cooling**:

- Remove the baffle from the jacket vent and introduce liquid nitrogen to cool the reactor to the desired temperature.

4. **Reaction**:

- Under nitrogen, slowly add n-butyl lithium to the reactor.

5. **Post-Reaction**:

- Add liquid nitrogen to the jacket, secure the vent cap, and circulate anhydrous alcohol to raise the temperature.

- Hold the reactor at the target temperature, then depressurize the alcohol in the jacket.

These steps ensure safe and efficient operation while maintaining the integrity of the reaction process.